![]() ![]() Melatonin regulates the circadian rhythm and affects sleep architecture. Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous hormone that interacts with membrane melatonin receptors MT1 and MT2, two different types of G-protein-coupled receptors expressed both in brain regions and peripheral tissues ( Pandi-Perumal et al., 2008 Pohanka, 2022). ![]() Sleep is regulated by circadian and homeostatic processes ( Saper et al., 2005 Borbély, 2022). Sleep disorders are the most prominent symptom in depressive patients ( Fang et al., 2019). In addition, many neuropsychiatric disorders, especially depression, can lead to sleep disorders. Stressful life events, related to work/school living, family, health, or indeterminate with negative emotional valence, are the most frequent triggers of insomnia ( Bastien et al., 2004 Drake et al., 2014). Increased levels of stress at night lead to decreases in slow wave sleep, sleep efficiency, and general sleep quality ( Kim and Dimsdale, 2007). A study has indicated that poorer sleep is associated with elevated feelings of stress in both individuals with sleep disorders and individuals from the general population ( Demichelis et al., 2022). Predisposing factors for sleep disorders include age, sex, environment, stress, irregular sleep-wake schedule, etc ( Billings et al., 2020 Meyer et al., 2022). Sleep is sensitive and can easily be affected. Sleep disorders are tightly linked with functional consequences like decreased attention and concentration, an increased risk of disease, lower work productivity, etc ( Battle, 2013). Circadian rhythm disorders include advanced or delayed sleep phase disorder and irregular sleep-wake rhythm ( Allega et al., 2018). Insomnia, the most prevalent type of sleep disorder, is characterized by difficulty in sleep initiation and maintenance ( Riemann et al., 2020). Sleep disorders include insomnia, narcolepsy, sleep apnea syndrome, circadian rhythm disorders, etc., affecting up to 40.49% population during 2019–2021 and becoming a significant public health concern ( Jahrami et al., 2022). Sleep disorders are commonly associated with neurological pathogenesis and may indicate some neurodegenerative processes ( Musiek and Holtzman, 2016). Sleep affects various physiological homeostasis and has a pivotal role in regulating the central nervous system functions ( Tononi and Cirelli, 2014 Cuddapah et al., 2019). The alteration of melatonin-related pathways was shown to trigger sleep disorders. These results identified sleep disorders in a mice model of chronic stress. Expression of downstream effectors to melatonin receptors was also affected. The transcription and expression of melatonin receptors were reduced, and circadian rhythm related genes were altered. ![]() Tryptophan and 5-hydroxytryptamine levels were increased in the hypothalamus, while melatonin level was decreased. Sleep fragmentation, circadian rhythm disorders, and insomnia exhibited in CRS-treated mice formed sleep disorders. Mice undergoing chronic restraint stress modeling for 28 days showed body weight loss and reduced locomotor activity. The study explored the melatonin-related mechanisms of stress-associated sleep disorders on a mouse model of chronic stress by exploring the alteration in sleep architecture, melatonin, and related small molecule levels, transcription and expression of melatonin-related genes as well as proteins. Stress may trigger sleep disorders and are also risk factors for depression. 4Department of Surgery, University of Toronto, Toronto, TO, Canada.3Institute of Molecular Medicine and Innovative Pharmaceutics, Qingdao University, Qingdao, China.2Institute of Drug Discovery Technology, Ningbo University, Ningbo, China.1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.Tian-Ji Xia 1, Zhi Wang 1, Su-Wei Jin 1, Xin-Min Liu 2, Yong-Guang Liu 1, Shan-Shan Zhang 1, Rui-Le Pan 1, Ning Jiang 1, Yong-Hong Liao 1, Ming-Zhu Yan 1*, Li-Da Du 3,4* and Qi Chang 1* ![]()
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![]() They play with the other kids, learn with the other kids, and most importantly, they socialize with the other kids. They do get external supports because, like all kids with hearing loss, spoken language acquisition is more difficult for them, but otherwise they are just like all the other kids. Children don't go to special schools or attend special classes. One of the important tenets of auditory verbal therapy is early introduction in a mainstream environment. It is a lot to ask of parents already fraying from the diagnosis.Įarlier mainstreaming leads to better socialization So now they have to learn sign language and teach it to their child while still doing all the things necessary for a child to learn spoken language. Most parents don't know sign language when they learn their child is deaf. There are speech therapy sessions to attend and mappings for implants and tunings for hearing aids and meetings with teachers. It takes a lot of effort for children with hearing loss to learn spoken language. Learning spoken language only reduces the stress on parents. Well, if spoken language is the goal for 95-99% of all cochlear implant candidate children, why even bother with sign? Parents that choose the cochlear implant are implicitly making the choice of spoken language, not ASL. ![]() There are no hard figures on this, but discussions with a number of the leading institutions in the country lands the number of parents choosing cochlear implantation for their eligible child at somewhere between 95-99%. Most parents of children that are candidates to get the cochlear implant choose the cochlear implant ![]() There are pretty obvious reasons why this approach would be a valuable management option for children with Usher who are at risk of losing their vision, but here they are in no particular order: Well, if the goal is the acquisition of spoken language, the AV approach concludes, the best way to accomplish this is by focusing solely on the acquisition of that language and no others. ![]() If you want to learn to speak French, the best way is to go to France and speak French. The idea is one of total immersion, no different than learning any other language. Unlike Total Communication (see part 1), the AV approach discourages the use of sign language for children with hearing loss for whom the goal is spoken language acquisition. One of the options for support of spoken language development is Auditory Verbal Therapy. Children that use digital hearing aids and cochlear implants that get the right supports can learn to speak and understand spoken language at a level on par with hearing children. While it is not a cure for hearing loss, it certainly can be considered a cure for the acquisition of spoken language. As stated earlier, the technology today allows people with hearing loss access to more sound than at any point in history. This is generally represented by the Auditory Verbal Therapy approach. To sign or not to sign is still the question before us, only this time we'll look at not to sign. In the absence of sound, the brain re-organises itself to receive input from other senses, primarily vision which results in increased use of gestures and other visual cues.To Sign or Not to Sign Part 3: Auditory Verbal Therapy The first three-and-a-half years of life are the most crucial years for development of the brain. Since listening happens through the brain, early implantation and appropriate therapy results in normal development of neural pathways to receive auditory information. AVT targets 5 domains: audition, language, speech, cognition and communication.The parent, therapist, and child engage in play activities that teach the child to use his or her amplified residual hearing to learn auditory-verbal communication like children with normal hearing.AVT is a ‘parent-centered’ approach that encourages the use of naturalistic conversation and the use of spoken language to communicate.AVT maximises the use of the child’s amplified residual hearing.Unless the sense of hearing is emphasized, these children continue to function as deaf and sound is completely meaningless to them.Īuditory-Verbal Therapy is a specialised type of therapy designed to teach a child to use the hearing provided by a hearing device for understanding speech and learning to talk. Once fitted with a hearing device, the child has to be trained to listen. For a child fitted with a hearing device, listening is not automatic, it requires practice. Hearing is when the sound reaches the ear, listening is when it reaches the brain. ![]() ![]() ![]() It will NOT be faster breaking all that up into separate torrents - you'd need to make 100 TIMES as many tracker updates along with all the participants just to accomplish the same thing as on 1 torrent. I'm hoping that I am making my request clear?Ĭurrently when I try to open a torrent a second time, uTorrent just says that its in my download list already and if i want to add the trackers. 24.3k Posted AugYou can already set file priority and even set files to not download. This will allow me (on my extremely slow line) to speed up the process dramatically, especially because I like to watch these downloads as they complete (set 2 or 3 files to high priority, next 2 or 3 to normal, and the rest to low). Files are live-transcoded into the native format for your device so you dont need to pre-convert your media. For example if I open this 58GB torrent consisting of 100 files 10 times, and select different files in each of the downloads, I will have 10 separate downloads in uTorrent downloading this big torrent. An engineer installs himself in a prison he helped design, in order to save his falsely accused brother from a death sentence.elow, we have provided the subs. StreamToMe is a media player application for Macs and iOS devices (iPad, iPhone and iPod Touch) that plays video, music and photo files (in a wide variety of formats) streamed over the network from another Mac or PC. ![]() What I would like to do is basically open the same torrent files (in one instance of uTorrent on the same machine) multiple times. StreamToMe is a media player application for Macs and iOS devices (iPad, iPhone and iPod Touch) that plays video, music and photo files (in a wide variety of formats) streamed over the network from another Mac or PC. To work around this bug temporarily, please follow these instructions: Try to set your desired username and password in ServeToMe. Apple claim theyre investigating the issue. I am currently downloading a huge torrent - 58GB - consisting of roughly 100 files. ServeToMe is a handy and reliable application that supports the StreamToMe application for iPhone and iPad. The cause is a bug in Apples Mountain Lion where applications signed with a Developer ID (like ServeToMe) are unable to read from the Keychain. I have been looking through the forum to see if this question has not answered elsewhere yet, but could not find anything - so please forgive me if I missed it. Stealth mode must be disabled, and there must be an entry named 'ServeToMe' or 'ServeToMe.app' that is set to 'Allow incoming connections'. ![]() ![]() ![]() The chances are that either you, or someone very close to you, could directly benefit from this new knowledge, given how prevalent insomnia is. “Insomnia is a solvable problem,” says Colin Espie at the University of Oxford. Insomnia a sleep disorder characterised by the. Simply put, we are now in a much better position to work out why someone has trouble sleeping – and the best way to bring them the rest they so desperately seek. An interrupted sleep cycle could have various impacts on your body, including fatigue and stress. This deeper understanding of how the brain can cause this debilitating condition means we have reached a turning point in its treatment. But an explosion in sleep research over the past few years has helped to identify the neurological and mental processes underlying it. Yet, for decades, scientists had struggled to offer a good solution. It is also one that has far-reaching health and economic impacts. That may be a familiar feeling for many: insomnia is a common condition. Parker’s character experienced such angst from her unwanted wakefulness that she considered “busting over the temple with a night-light”. Difficulty falling asleep, or staying asleep, inevitably leads to being less than fully awake and refreshed during the daylight hours for years I felt like I was half of myself. Common causes of chronic insomnia include: Stress. Treating the underlying cause can resolve the insomnia, but sometimes it can last for years. Chronic insomnia is usually a result of stress, life events or habits that disrupt sleep. The more you try to create the right conditions for sleep, the more elusive it appears the very desire makes it impossible to achieve. Insomnia may be the primary problem, or it may be associated with other conditions. You will almost certainly relate to this frustration if you have ever found it difficult to nod off. Stimulants, such as caffeine, aren’t enough to override your body’s profound need for sleep. However, a sleep-medicine specialist can likely dig deeper into the causes of your insomnia and offer more ways to resolve it. Your primary care provider may be able to treat your problem. Im not too familiar with The Machinist but Ill tell yall about my experience if youre interested. If your insomnia is severe or chronic enough that it’s affecting your quality of life, it’s time to call a doctor. Saw a request from jypastl for someone with chronic insomnia so here I am. “Early to bed, and you’ll wish you were dead. Go to IAmA r/IAmA Posted by deleted IAmA person who has had chronic insomnia for 9 years. How do people fall asleep? I’m afraid I’ve lost the knack,” muses the unnamed protagonist in Dorothy Parker’s 1933 short story The Little Hours. ![]() ![]() Place a layer of parchment paper between layers. Place them in a freezer-friendly container, making sure they aren’t touching. Store it in the refrigerator if it begins to soften/melt in warm weather.įreeze individual pecan bars by first allowing them to cool completely after baking. Store in an airtight container, at room temperature for 1 week. Use a thickened cream, also known as heavy cream in the US.Pure maple syrup works best, not maple syrup with added sweeteners.Use pecan halves for best results or use whole pecans and roughly chop them.This makes it easier for you to rub it into the flour to create the dough. The butter for the shortbread base must be soft at room temperature.Allow them to cool before slicing into squares or longer bars. Then boil for 2 minutes.ĥ) Turn off the heat and stir through the pecans.Ħ) Pour the topping over the base. Warm through until the butter has melted. Bake for 15-18 minutes.Ĥ) In a pot, add the butter, sugar, maple syrup, and cream. There is a full and detailed recipe card at the bottom of this post.ġ) In a large mixing bowl whisk together flour, and sugar.Ģ) Rub the softened butter into the flour until it turns crumbly.ģ) Firmly press the dough into the pan. Thickened cream - also known as heavy cream in the US.Maple syrup - a pure maple syrup works best with no added sweeteners. ![]() Pecans - use pecan halves or whole pecans roughly chopped.Measure your sugar by lightly packing it into the measuring cup or use kitchen scales to measure the weight. Brown sugar - use light/regular brown sugar, not dark brown sugar.Plain flour - is also known as all-purpose flour in the US.You can use unsalted butter, just be sure to add ¼ teaspoon of fine salt or Kosher salt to both the base and topping. Salted butter - must be soft at room temperature before starting your pecan bars.Here is what you need to make these easy pecan shortbread bars: If you’re interested in more easy dessert recipes, try my Almond Slice, Quick & Easy Apple Crumble, Sticky Date Pudding, and this Raspberry Chocolate Semifreddo. During Thanksgiving and the festive holiday season, serve the bars cold from the fridge with scoops of ice cream as a refreshing dessert. If you live in Australia, enjoy making this recipe for pecan bars all year round. Serve with vanilla ice cream by the fireplace. You can warm the squares up in the oven so they’re nice and warm. Make these pecan shortbread bars as a Thanksgiving dessert that the whole family can enjoy. With the added crunch from the pecan topping and the melt-in-your-mouth shortbread crust, these pecan squares are a crowd pleaser. You can serve these bars as a delicious pecan dessert warmed up and served with scoops of vanilla ice cream. The rich caramel and maple pecan topping is made without corn syrup, making this a healthier version of pecan bars. These bars are a take on the traditional pecan pie, a classic and popular American dessert. This recipe for easy pecan pie shortbread bars is created with a 3 ingredient shortbread base and an indulgent brown sugar and maple caramel pecan topping made without corn syrup. Serve as a warm pecan dessert with ice cream.These gooey pecan dessert bars are delicious! ⭐ Why You Will Love This Recipe With a shortbread crust topped with pecans coated in a quick caramel sauce. As always, we toasted the pecans first, because the aroma and the flavor of pecans (or almost any nut for that matter) are enhanced when toasted.If you love pecan pie, you’ll love these easy 6 ingredients Pecan Shortbread Bars. ![]() These Toasted Pecan Shortbread Squares are our new version of “Two Bakes” and we are so pleased with the result. So, back to the drawing board I went to try to recreate them! But, when I remembered about these cookies and wanted to bake them for this year’s holiday cookie connection, I couldn’t find the recipe anywhere … not in my recipe box nor in hers, or my sister’s either. I am positive that I copied the recipe when I was in high school and had the time to rewrite all of her recipes out on brand new recipe cards. ![]() They were so yummy with a shortbread crust and a nutty sweet filling on top. That was because we baked them twice, once for the crust and again for the topping. When I was a kid, my mom had a delicious recipe for cookie squares that we simply called ”Two Bakes”. ![]() ![]() ![]() Certain trimmers can charge in just one minute if all you need is a quick shave. For cordless trimmers, you’ll need to pay close attention to charging time and battery life.So unless you plan to wander around while trimming, this could be a handy feature to have. You won’t have to worry about your battery running out before you finish. Cordless trimmers have their benefits, but having a cord can come in handy, as well.Just open the drain and let the water flow through. Some beard trimmers have a built-in water drain. Cleaning is always a little extra work with a beard trimmer. ![]() Some trimmers are lightweight, which makes a big difference if shaving is taking a while. Consider a trimmer with a non-slip body with a rubber grip that keeps you comfortable while also giving you the control you need.
![]() ![]() On top of that, the app continues to run as reliably and smoothly as ever.Īll that being said, however, I’ve found the “Notes” option for results less and less useful because of the inability to filter test results so that those with notes can be viewed separately. Just a great idea that provides very, very useful information in terms of gauging in-the-moment download/upload bandwidth capacity. The latest update introducing separate “multi” and “single” connections testing was a dandy. Sorry again, and thanks for using Speedtest! Sorry for the trouble! This issue should now be fixed in the most recent update, 5.0.2. Maybe I should’ve created a new account? Your account creation process has been confusing and buggy so maybe it’s just a glitch? Hopefully the next app update might fix this issue, I can’t be the only one having this issue, there should also be an option to sync your speed tests with iCloud like Shazam and allow us to import our CSV files that we exported prior to our tests disappearing. I really need your help to re-add all my speed tests back to the app, it would mean a lot if you could reply to this, I loved Speedtest so much but now I feel like it’s a little pointless if all of my speed tests are now gone. Once updating the app, and signing in, all of my Speedtest were gone, over two years worth of speedtests taken on Verizon, T-Mobile, and AT&T and Wi-Fi, but for some reason all my video tests are still there. I’ve loved this app over the past few years and I saw the latest Speedtest app update and I thought that it would be a great idea to update and sign in to my account to sync all of my speedtests but nooo that was a horrible idea. Loved this app but latest Speedtest update when signing into my account I removed all my Speedtests Go ad free! If you’d like to enjoy Speedtest without ads, we provide the option of removing ads from Speedtest for $0.99. Track past tests with detailed reporting Troubleshoot or verify the speed you were promised Test with a single connection to simulate downloading a file or multiple connections to understand max speed Real-time graphs show connection consistency Stay private and secure with our free Speedtest VPN Take a video test to measure your max resolution, load time, and buffering View mobile carrier coverage with Speedtest Maps Measure ping at 3 stages: idle, download, and upload ![]() Discover your download, upload, and jitter Millions of users have made Speedtest the #1 app for testing internet speed, and it’s trusted daily by professionals throughout the industry: ![]() Speedtest VPN Premium users will also receive no advertisements while their subscription is active. Use up to 2GB of data over VPN per month for free, or go Premium with unlimited usage for just $4.99 monthly. Keep your online connection private and secure with Speedtest VPN™. Take a video test to get actionable insights that help you optimize your online video experience. Video testing empowers you with a real-time assessment of your network’s current streaming quality. Easily switch between providers and regions to compare coverage in the locations you frequent. See performance by provider to find out where you’re likely to experience strong connectivity. Use Speedtest® for a quick, easy, one-tap connection internet speed test-accurate anywhere thanks to our global server network.Įxplore mobile network coverage with Speedtest Maps based on real-world data gathered by the Speedtest app. ![]() ![]() ![]() While these ad blockers didn’t make the top three, they are worthy of consideration: As the software’s subscribe page reads, “For now, the subscription does not unlock any additional features, but it helps us.”Īt least they’re honest about how they earn money! Without using a program like Acceptable Ads, a subscription model is one way the company can earn revenue. Ghostery does have a subscription option, but as far as I can tell, the only reason to “subscribe” is to support the software developers. You can also whitelist sites from this GUI as well. One of the extension’s best features is its toolbar dashboard which shows various metrics like page-load speed and number of elements blocked. Regardless of your stance on the controversy, the “Acceptable” Ads feature can be disabled at any time with a few clicks– here’s how: With Acceptable Ads, Adblock Plus is now profiting from the very thing it was built to prevent: advertisements! It’s like a personal trainer holding sessions at the back of his doughnut shop. ![]() Philosophically, I can empathize with those who criticize ABP. The “feature” is turned on by default in ADP, allowing ads that “ have been identified as non-annoying and non-disruptive to the user’s experience.”Ĭoming from the creators of a program called AdBlock Plus, intentionally allowing any ads was unacceptable for many users. In 2011, Eyeo, the parent company of Adblock Plus, created an initiative called Acceptable Ads. The app came to the Google Chrome browser in 2010 and Safari in 2014.įree and open-source, the ad blocker would be the first choice for many were it not for the controversy surrounding its Acceptable Ads program. ![]() The program started as a Firefox add-on in 2006 as a spinoff of a program called Adblock.
![]() To maximize the effectiveness of your storms, you’ll want the following Druid Spirit Boons: Here are the skills that you should unlock for a solid Storm magic-focused Diablo 4 Druid build: The Perfect Storm Key Passive rounds this out, helping you deal even more damage to Vulnerable enemies and will generate a little extra Spirit. Both deal lots of Lightning damage and can apply numerous crowd control effects to enemies, giving you ample protection from any enemies in melee range. Your Ravens will chip away at enemies but will also help your Critical Strike chances and will make enemies Vulnerable when they’re caught in the flock.įor plenty of AoE damage that follows you around, the Hurricane Wrath Skill and Cataclysm Ultimate Skill will have you covered – almost quite literally. Since this Diablo 4 Druid build is not naturally that resilient, Cyclone Armor adds a bit of protection and helps you apply several status ailments to enemies that get too close. Follow up with the Lightning Storm Skill to create a storm that grow more powerful the longer it’s channeled. Start with Storm Strike as your Basic Skill to deal a little lightning damage that has a chance to both immobilize and enemies it hits and make them Vulnerable. The Druid’s storm and earth nature magic can be mixed and matched, but this build focuses solely on the use of Storm magic Skills that can protect you and damage enemies at almost all ranges. Although, you won’t unlock this mechanic until you’ve completed the ‘Druid: Spirits of the Lost Grove’ Priority quest which automatically gets added to your Diablo 4 quest log at Level 15. These include things like increasing your maximum health or Spirit, increasing your attack speed, or adding new ways to become Fortified. With the Spirit Boons mechanic, Druids can apply a selection of Animal Sprit Boons that add or enhance certain powers, adding to your Druid build’s power, along with its Skills, Aspects, and more. Damage types: Physical, Lightning, Poison. ![]() Druid weapons: Two-Handed Axes, Two-Handed Maces, Two-Handed Swords, Axes, Maces, Swords, Staves, Totems.Class mechanic: Spirit Animals – Give Spirit Offerings to four animal spirits to unlock and equip useful boons.Skill Resource: Spirit – using Basic Skills generates Spirit.Role: Melee, spellcasting, AoE, crowd control.Here’s a quick rundown of how they work in Diablo 4: This variety does also mean they can feel like a master-of-none class at times, and they’re lacking in mobility options, but broadly, the best Diablo 4 Druid builds are great for AoE damage, crowd control, and being slightly lesser tanks compared to Barbarians. This variety means that Druids are excellent for creating either highly specialized or general builds. ![]() The Druid class in Diablo 4 employs a mix of melee weaponry, elemental spells, shapeshifting, and animal summons. ![]() ![]() ![]() ![]() Therefore, in our offer of studs, we offer several chemical formulas, such as serotonin or dopamine earrings. Chemical formulas in jewelry are very popular. In their large group you will find fashionable designs such as: moon earrings, horse earrings, zirconia studs and more sophisticated pearl earrings. Another interesting proposition is the ear harp earring findings, which is a type of fastener also often used to hang other decorations.ĭue to their subtle look, practicality and convenience, earring studs for jewelry making are very popular. A popular pattern in this category with a similar fastening method are lever back hoop earrings, which are often used to earring project with precious stones or solo statement earring. In our wide range of earring findings, you will find models with a loop and pins for hanging, as well as with a pinch bail, a bowl for gluing and filling with epoxy resin or other jewellery clays. ![]() They are also the right choice for the project of more massive earrings or earrings to wear in winter. In addition, these semi-finished products themselves are decorative elements, so if you ultimately want to make earrings, for example, only with stones or pendants – it is worth attaching them to leverbacks, instead of ordinary earring posts or silver earring wires. This is also the reason why this earring design is often chosen for precious stones, crystals or pearls. It is more durable and slightly more massive than the other types of earring bases, because it has a mechanical clasp, so it is unlikely to lose the earring by accidental unfastening. In a wide group of elements for earrings, the leverback findings occupy a rather unique place. The lever back earring closure belongs to the models closed with a latch. Earrings created on open hooks can be additionally secured with locking earring backs. The advantage of these most popular jewelry findings is the ease and speed of putting on and off. And in the winter, such earrings can catch on hats and scarves, so it’s easy to lose beautiful ornaments then. Jewelry constructed on their basis is also not recommended for sports or dancing, because it can fall out of the ears relatively easily. Open wires, an example of which are also fish hooks, do not have a clasp, so it is recommended that earrings made on them be removed before going to bed. We also distinguish variants with flattened wire, pins, cups for pasting, bails, as well as decorated with wings, flowers, hearts and crystals. Some models are decorated with an additional ball and spring. Most often, these are silver earring hooks ended with a loop for connecting with other elements. They are the simplest group of jewelry supplies for earring making. Open earring hooks for jewelry making, as the name suggests, do not have any protection in the form of closure. Production of silver and gold jewellery.Laser cutting services of silver and gold. ![]() |
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